Fans have been curious to know whether Rena Sofer’s beloved character, Lois Cerullo, is leaving *General Hospital*. The actor returned to the show in 2023, much to the delight of fans. However, it now appears that her time on the soap opera has come to an end—at least for the moment. Here is everything you need to know about Lois’s exit from the longest-running series.
### Is Rena Sofer’s Lois Really Leaving *General Hospital*?
Yes, Rena Sofer’s Lois Cerullo is leaving *General Hospital*. Soap Opera Digest has confirmed the seasoned actor’s departure from the show. In the October 24, 2025 episode, Lois was seen emotionally bidding farewell to her daughter, Brook Lynn Quartermaine.
Lois has left town for Seoul, South Korea, to take over the position of tour manager for Blaze, marking a significant new chapter in the character’s story.
### A Look Back at Rena Sofer’s Journey on *General Hospital*
For those who may not know, Rena Sofer began her role as Lois Cerullo in 1993. Her portrayal received positive reviews from viewers, establishing Lois as a memorable character on the show.
Sofer initially decided to exit the series in 1996, as she was about to welcome her first daughter with then-husband Wally Kurth. She made a brief return in 1997 to wrap up Lois and Ned’s storyline.
After a long hiatus, Rena Sofer made a full comeback to *General Hospital* in 2023. Around the same time, she and her husband, Sanford Bookstaver, relocated to the East Coast, moving full-time to New York.
### Rena Sofer Reflects on Her Role and Fan Support
Speaking about her return to *General Hospital*, Sofer told Soap Opera Digest,
> “I’ve played a lot of characters in my career, and Lois is probably one of the top three characters I’ve ever played in 37 years of being an actress. So to be able to go back and do it was unreal.”
She also expressed her gratitude to fans who eagerly awaited her comeback:
> “If they hadn’t spent the last 27 years constantly making little buzzing noises about Lois coming back or me coming back as Lois, I wouldn’t be in this position. It’s inspiring, and I am forever grateful.”
### Is There a Chance for Lois to Return?
While Rena Sofer has left the show for now, there is certainly room for Lois Cerullo’s return in the future. Before leaving, Lois assured her daughter Brook,
> “The second you need me, I will drop everything and come running.”
*General Hospital* continues to air on ABC, keeping fans eager to see what comes next for their favorite characters.
https://www.comingsoon.net/guides/news/2048840-general-hospital-rena-sofer-lois-leaving